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Tunstall Industries Group

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Easton Green
Easton Green

Forensic Analysis On The Cutting Edge: New Meth... __LINK__



In the present work, a highly efficient modified LC-ESI-MS/MS method was developed and validated for the simultaneous determination of MA and N-IBA in forensic samples. The method exhibited excellent selectivity, linearity, accuracy, precision, and stability with a significantly lower LLOD and LLOQ than those in previous studies. When the method was applied to identify MA and N-IBA in several suspected samples in forensic cases, the MA and N-IBA were well separated and quantified. This work could offer new improvements for the forensic routine analysis of MA and N-IBA in suspected drug samples for clinical and forensic laboratories.




Forensic Analysis on the Cutting Edge: New Meth...



In forensic drug chemistry, analysts use scientific findings to help investigators pursue legal action against individual(s) suspected of a drug-related crime. The goal of forensic drug chemistry is to determine whether the material submitted contains an illegal substance. Based on the results of the analysis, law enforcement can pursue criminal charges and the court can determine appropriate sentencing.


MS has been routinely used in forensic science since the 1990s and is the widely accepted as the most accurate and reliable method of chemical analysis in forensics, thanks to its combination of benefits including high selectivity and sensitivity. As a result, typical forensic science laboratories employ a range of MS-based methods.


MS involves ionizing the compounds in a sample and separating the ions based on their mass-to-charge ratio to produce a spectrum, which can be interpreted to determine the chemical structure of the compounds present. MS is employed in a wide range of forensic applications including drug analysis, toxicology, arson investigations, and analyzing explosive, gunshot, and other trace residues. Forensic laboratories rely on standard analytical techniques like gas chromatography (GC)-MS and liquid chromatography (LC)-MS which use chromatography to separate molecules prior to analysis by MS.


The Pittcon 2019 Expo will feature suppliers of instrumentation for standard MS techniques, such as GC-MS, and cutting-edge techniques, like MALDI-MSI. Thermo Fisher Scientific will display their complete GC-MS solutions that can meet the routine demands of forensic laboratories, while Bruker Daltonics will exhibit their MALDI-MSI solutions, and JEOL will present high-resolution mass spectrometers.10-13


In addition to the cutting-edge science presented by Dr Brim and Dr Bouslimani at Pittcon symposia, the Pittcon Expo will feature all the leading companies supplying analytical instrumentation required for forensic profiling. Pittcon 2019 is the ideal place to meet the experts and learn more about the potential of microbiome and chemical residue analysis for forensic profiling.


MS imaging (MSI) is a relatively new and promising technique for forensic analysis. MSI provides spatially resolved maps of compounds within a sample by scanning the entire sample and providing mass spectra for each pixel within the image.


MALDI-MSI uses laser energy to ionize large molecules with minimal fragmentation, making it ideal for rapid identification of large and fragile molecules. MALDI-MSI is particularly suitable for forensic analysis as it provides very high sensitivity, label-free detection, and unbiased molecular characterization. Furthermore, MALDI-MSI can measure the distribution of a large number of analytes at one time, making it a rapid technique that can help to reduce back-log in forensic laboratories.


Traditionally, crime scene investigators have collected samples from crime scenes and taken them back to the laboratory for forensic analysis. As a result, routine analyses such as controlled substance analyses contribute significantly to the workload of forensic laboratories, which often have a backlog, resulting in slow results and impeding criminal investigations.


Identification of drugs, bodily fluids, and other unknown substances at crime scenes is traditionally conducted by making presumptive identifications and obtaining samples at the scene, before sending them to a forensic laboratory for analysis.


The Pittcon 2019 program is packed with relevant presentations, symposia, short-courses, and exhibitions making it an essential event for forensic scientists. The 2nd Annual Forensic Science Symposium will be of particular interest to forensic scientists, with speakers covering topics including forensic profiling, residue analysis, fingerprint mapping, on-scene analysis, new psychoactive substance analysis, and many more.


At the Pittcon Expo, exhibitors will present the latest portable and laboratory equipment for forensic analysis including GC-MS and LC-MS from Thermo Fisher Scientific and Shimadzu, Raman microscopes from Renishaw, MALDI-MSI solutions from Bruker Daltonics, DART-MS from JEOL, forensic light sources from HORIBA, and a plethora of other analytical solutions from leading suppliers.


The 2019 Pittcon Conference and Expo is a must-attend event for scientists and researchers wishing to learn about the latest trends in forensic analysis. The Pittcon Conference and Expo takes place March 17th-21st, 2019 at the Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA. 041b061a72


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